Treatment of covid-19 pneumonia with convalescent plasma therapy a case series
ARDS resolved in 4 patients at 12 days after transfusion, and 3 patients were weaned from mechanical ventilation within 2 weeks of treatment.
1. Introduction
Of the 5 patients, 3 have been discharged from the hospital length of stay: 53, 51, and 55 daysand 2 are in stable condition at 37 days after transfusion. Conclusions and relevance: In this preliminary uncontrolled case series of 5 critically ill patients with COVID and ARDS, administration of convalescent plasma containing neutralizing antibody was followed by improvement in their clinical status. The use of icosapent ethyl as supportive therapy for the treatment of moderate to severe coronavirus disease COVID pneumonia was recently described in a case series treatment of covid-19 pneumonia with convalescent plasma therapy a case series in the American Journal of Case Reports. The authors wrote, "In addition to the fact that more than 14 million confirmed cases have been reported, the actual burden of the virus is underestimated; of the numerous confirmed cases, there is a substantially greater amount of people that have actually been exposed or infected by the virus".
The respiratory sequelae morbidity commonly associated with SARS-CoV-2 infection are not solely caused by the viral infection itself, but also by an over-activated inflammatory host immune response, marked by an overall increase in inflammatory markers. Several studies involving corticosteroids and other immunosuppressants have been proposed, and clinical trials are well underway. Icosapent ethyl, a form of eicosapentaenoic acid with anti-inflammatory activity, has been approved as an adjunctive treatment with statins in patients with hypertriglyceridemia.
Icosapent ethyl is currently undergoing clinical trials to determine its anti-inflammatory effects in patients with coronavirus disease COVID Secondary Outcome Measures : Adverse events [ Time Frame: The reporting period for AEs starts at inclusion and ends at the final follow-up visit 2 months after inclusion. The safety of the intervention will be assessed with regard to AEs, baseline medical conditions, and findings from the physical examination and laboratory tests.
Possible adverse events will be elicited using a modification and Swedish translation appendix 6 of Common Terminology Criteria for Adverse Events v5. This uncontrolled case series examined five patients with laboratory-confirmed COVID, treated with plasma from five donors, ages 18 to 60, who had recovered from the infection, and tested negative for this and other respiratory and bloodborne viruses. Five critically ill COVID patients at Shenzhen Third People's Hospital, ranging from age 36 to 73, two of whom were women, had all received antiviral agents and steroids.
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None were smokers and four of five had no pre-existing medical conditions one had hypertension and mitral article source.
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Physicians should be aware of this potentially useful treatment ampeblumenau.com.br by: Feb 18, · In the attempt to stop this pandemic, especially in severe cases, there have been several interventions evaluated in randomized controlled trials for the treatment of COVID [2, 4, 5]. Convalescent plasma (CP) therapy is a classic and old immunotherapy, whose main determinant of efficacy is its neutralizing ampeblumenau.com.br: Alejandro Piscoya, Luis Fernando Ng-Sueng, Luis Fernando Ng-Sueng, Angela Parra del Riego, Renato Ce. May 07, · A synergistic role of convalescent plasma and mesenchymal stem cells in the treatment of severely ill COVID patients: A clinical case report. Stem Cell Res. Ther.  ; doi: /sCited by: 1. |
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